Height as a potential indicator of early life events predicting Parkinson's disease: A case‐control study
Identifieur interne : 002854 ( Main/Corpus ); précédent : 002853; suivant : 002855Height as a potential indicator of early life events predicting Parkinson's disease: A case‐control study
Auteurs : Paolo Ragonese ; Marco D'Amelio ; Graziella Callari ; Fabio Aiello ; Letterio Morgante ; Giovanni SavettieriSource :
- Movement Disorders [ 0885-3185 ] ; 2007-11-15.
English descriptors
Abstract
Aim of this study was to investigate the relationship between height in young adult age and Parkinson's disease (PD) risk. We included 266 persons affected by idiopathic PD. Patients were matched by age and sex to 266 controls by a random selection from the municipality of residence. We collected information about height preceding PD from official documents where these characteristics referred to young adult age (nearly 30 years). We compared height in cases and controls by calculating differences in mean distribution and by χ2 analyses. Crude and adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression models. Mean height was significantly lower in persons affected by PD compared to controls (P = 0.03). Difference was significant only in men (P = 0.001). Logistic regression models showed an inverse association between height and PD (OR 0.35; CI 0.16, 0.79; P < 0.01 comparing individuals in the highest percentiles of height with those in the lowest). Our results indicate an association between height and PD in men. Considering that dopamine sensitivity in the hypothalamic‐pituitary axis is related to adult height, our findings suggest a relationship between PD and factors modulating somatic growth early in life. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21728
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ISTEX:54E294A8ADE7D1950E1FE886E2C4AB4E8069E9A7Le document en format XML
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We included 266 persons affected by idiopathic PD. Patients were matched by age and sex to 266 controls by a random selection from the municipality of residence. We collected information about height preceding PD from official documents where these characteristics referred to young adult age (nearly 30 years). We compared height in cases and controls by calculating differences in mean distribution and by χ2 analyses. Crude and adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression models. Mean height was significantly lower in persons affected by PD compared to controls (P = 0.03). Difference was significant only in men (P = 0.001). Logistic regression models showed an inverse association between height and PD (OR 0.35; CI 0.16, 0.79; P < 0.01 comparing individuals in the highest percentiles of height with those in the lowest). Our results indicate an association between height and PD in men. Considering that dopamine sensitivity in the hypothalamic‐pituitary axis is related to adult height, our findings suggest a relationship between PD and factors modulating somatic growth early in life. © 2007 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Paolo Ragonese MD, PhD</name><affiliations><json:string>Dipartimento Universitario di Neuroscienze Cliniche, Università di Palermo, Palermo, Italy</json:string></affiliations></json:item><json:item><name>Marco D'Amelio MD</name><affiliations><json:string>Dipartimento Universitario di Neuroscienze Cliniche, Università di Palermo, Palermo, Italy</json:string></affiliations></json:item><json:item><name>Graziella Callari MD</name><affiliations><json:string>Dipartimento Universitario di Neuroscienze Cliniche, Università di Palermo, Palermo, Italy</json:string></affiliations></json:item><json:item><name>Fabio Aiello PhD</name><affiliations><json:string>Dipartimento di Statistica e Scienze Matematiche “S. 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Vianelli”, University of Palermo, Palermo, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento di Neurologia, Università di Messina, Messina, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">epidemiology</keyword><keyword xml:id="kwd3">risk factors</keyword><keyword xml:id="kwd4">height</keyword><keyword xml:id="kwd5">anthropometric measures</keyword></keywordGroup><fundingInfo><fundingAgency>Italian Ministry for University and Research (MIUR)</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Aim of this study was to investigate the relationship between height in young adult age and Parkinson's disease (PD) risk. We included 266 persons affected by idiopathic PD. Patients were matched by age and sex to 266 controls by a random selection from the municipality of residence. We collected information about height preceding PD from official documents where these characteristics referred to young adult age (nearly 30 years). We compared height in cases and controls by calculating differences in mean distribution and by χ<sup>2</sup> analyses. Crude and adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression models. Mean height was significantly lower in persons affected by PD compared to controls (<i>P</i> = 0.03). Difference was significant only in men (<i>P</i> = 0.001). Logistic regression models showed an inverse association between height and PD (OR 0.35; CI 0.16, 0.79; <i>P</i> < 0.01 comparing individuals in the highest percentiles of height with those in the lowest). Our results indicate an association between height and PD in men. Considering that dopamine sensitivity in the hypothalamic‐pituitary axis is related to adult height, our findings suggest a relationship between PD and factors modulating somatic growth early in life. © 2007 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Height as a potential indicator of early life events predicting Parkinson's disease: A case‐control study</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Height and Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Height as a potential indicator of early life events predicting Parkinson's disease: A case‐control study</title></titleInfo><name type="personal"><namePart type="given">Paolo</namePart><namePart type="family">Ragonese</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Dipartimento Universitario di Neuroscienze Cliniche, Università di Palermo, Palermo, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marco</namePart><namePart type="family">D'Amelio</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento Universitario di Neuroscienze Cliniche, Università di Palermo, Palermo, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Graziella</namePart><namePart type="family">Callari</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento Universitario di Neuroscienze Cliniche, Università di Palermo, Palermo, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fabio</namePart><namePart type="family">Aiello</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Dipartimento di Statistica e Scienze Matematiche “S. Vianelli”, University of Palermo, Palermo, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Letterio</namePart><namePart type="family">Morgante</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Neurologia, Università di Messina, Messina, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giovanni</namePart><namePart type="family">Savettieri</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento Universitario di Neuroscienze Cliniche, Università di Palermo, Palermo, Italy</affiliation><description>Correspondence: Dipartimento Universitario di Neuroscienze Cliniche, University of Palermo, Via Gaetano La Loggia 1–90129 Palermo, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-11-15</dateIssued><dateCaptured encoding="w3cdtf">2007-02-20</dateCaptured><dateValid encoding="w3cdtf">2007-08-15</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">24</extent><extent unit="words">3905</extent></physicalDescription><abstract lang="en">Aim of this study was to investigate the relationship between height in young adult age and Parkinson's disease (PD) risk. We included 266 persons affected by idiopathic PD. Patients were matched by age and sex to 266 controls by a random selection from the municipality of residence. We collected information about height preceding PD from official documents where these characteristics referred to young adult age (nearly 30 years). We compared height in cases and controls by calculating differences in mean distribution and by χ2 analyses. Crude and adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression models. Mean height was significantly lower in persons affected by PD compared to controls (P = 0.03). Difference was significant only in men (P = 0.001). Logistic regression models showed an inverse association between height and PD (OR 0.35; CI 0.16, 0.79; P < 0.01 comparing individuals in the highest percentiles of height with those in the lowest). Our results indicate an association between height and PD in men. Considering that dopamine sensitivity in the hypothalamic‐pituitary axis is related to adult height, our findings suggest a relationship between PD and factors modulating somatic growth early in life. © 2007 Movement Disorder Society</abstract><note type="funding">Italian Ministry for University and Research (MIUR)</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>epidemiology</topic><topic>risk factors</topic><topic>height</topic><topic>anthropometric measures</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>15</number></detail><extent unit="pages"><start>2263</start><end>2267</end><total>5</total></extent></part></relatedItem><identifier type="istex">54E294A8ADE7D1950E1FE886E2C4AB4E8069E9A7</identifier><identifier type="DOI">10.1002/mds.21728</identifier><identifier type="ArticleID">MDS21728</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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